Apologies for the delay in replying.
With the region selected on the world map, hold shift and click the reset ai button that appears. Hopefully that will let the region load, though it may take awhile if there are lots of villagers and monsters on the map. Also best to not use that function unless we ask you to, as we sometimes need to save for Ray to poke at to help fix the problem.
I also recommend using the steam forums for RtR instead of here, as these forums are not checked that often.
Dooming the world resets the world map goals, yes. Before you do that, you could see if reseting the AI provides a temp fix for it. To do that, select the region on the world map, hold shift, and click the reset ai button that should now be visible. Best to avoid using that unless we ask you to try it, as it can potentially make things worse, depending on the exact situation.