Whenever you start a new profile, the "Screenshake Enabled" setting is always set to true, no matter what it had been in your previous profiles. Similarly, the "Tips Enabled" setting always defaults to true on the "Create New Profile" screen. There may be other settings which behave in similar ways, but these are the two I've noticed.
It would be nice if the "Create New Profile" screen would give all available options instead of just "Tips Enabled" and the Twitch thing. It would be even nicer if everything would default to the same as you had for the most recent previous profile (even if you're not given any more options on "Create New Profile").